Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

The Sinclair Method (TSM) is a science-backed approach that helps individuals reduce alcohol consumption through pharmacological extinction. By taking Naltrexone before drinking, people gradually lose the urge to consume alcohol excessively. Unlike traditional abstinence-based models, TSM allows for controlled drinking, making it an appealing choice for those who want to develop a healthier relationship with alcohol.
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